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An increasing number of studies have demonstrated the significant roles of the interplay between microenvironmental mechanics in tissues and biochemical-genetic activities in resident tumor cells at different stages of tumor progression. Mediated by molecular mechano-sensors or -transducers, biomechanical cues in tissue microenvironments are transmitted into the tumor cells and regulate biochemical responses and gene expression through mechanotransduction processes. However, the molecular interplay between the mechanotransduction processes and intracellular biochemical signaling pathways remains elusive. This paper reviews the recent advances in understanding the crosstalk between biomechanical cues and three critical biochemical effectors during tumor progression: calcium ions (Ca 2+ ), yes-associated protein (YAP), and microRNAs (miRNAs). We address the molecular mechanisms underpinning the interplay between the mechanotransduction pathways and each of the three effectors. Furthermore, we discuss the functional interactions among the three effectors in the context of soft matter and mechanobiology. We conclude by proposing future directions on studying the tumor mechanobiology that can employ Ca 2+ , YAP, and miRNAs as novel strategies for cancer mechanotheraputics. This framework has the potential to bring insights into the development of novel next-generation cancer therapies to suppress and treat tumors. 

Measurements are presented of the cross-section for the central exclusive production ofJ/\psi\to\mu^+\mu^- $J/\psi \to {\mu }^{+}{\mu }^{-}$and\psi(2S)\to\mu^+\mu^- $\psi \left(2S\right)\to {\mu }^{+}{\mu }^{-}$processes in proton-proton collisions at\sqrt{s} = 13 \ \mathrm{TeV} $\sqrt{s}=13TeV$with 2016–2018 data. They are performed by requiring both muons to be in the LHCb acceptance (with pseudorapidity2<\eta_{\mu^±} < 4.5 $2<{\eta }_{{\mu }^{\pm }}<4.5$) and mesons in the rapidity range2.0 < y < 4.5 $2.0<y<4.5$. The integrated cross-section results are\sigma_{J/\psi\to\mu^+\mu^-}(2.0 ${\sigma }_{J/\psi \to {\mu }^{+}{\mu }^{-}}(2.0<y_{J/\psi }<4.5,2.0<{\eta }_{{\mu }^{\pm }}<4.5)=400\pm 2\pm 5\pm 12pb,{\sigma }_{\psi \left(2S\right)\to {\mu }^{+}{\mu }^{-}}(2.0<y_{\psi \left(2S\right)}<4.5,2.0<{\eta }_{{\mu }^{\pm }}<4.5)=9.40\pm 0.15\pm 0.13\pm 0.27pb,$where the uncertainties are statistical, systematic and due to the luminosity determination. In addition, a measurement of the ratio of\psi(2S) $\psi \left(2S\right)$andJ/\psi $J/\psi$cross-sections, at an average photon-proton centre-of-mass energy of1\ \mathrm{TeV} $1TeV$, is performed, giving$ = 0.1763 ± 0.0029 ± 0.0008 ± 0.0039,$$ where the first uncertainty is statistical, the second systematic and the third due to the knowledge of the involved branching fractions. For the first time, the dependence of theJ/\psi$ $J/\psi$and\psi(2S) $\psi \left(2S\right)$cross-sections on the total transverse momentum transfer is determined inpp $pp$collisions and is found consistent with the behaviour observed in electron-proton collisions.